For example after downregulation of Kiaa0319 expression in rats via shRNA, significant adult rapid auditory processing impairments were reported, along with cortical anomalies reflecting atypical neuronal migration. Animal models targeting the rodent homolog ( Kiaa0319) have been used to explore putative behavioral and anatomic anomalies, with mixed results. Several candidate risk genes have also been identified, with KIAA0319 as a main candidate. Although underlying biological and genetic mechanisms remain unclear, anomalies in phonological processing and auditory processing have been associated with dyslexia. Type, OpenType.Developmental dyslexia is a common neurodevelopmental disorder characterized by difficulties in reading and writing.
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